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FIGURE 2-3 Glycation of proteins is thought to play a role in the aging process of lysine and arginine of collagen and ECM proteins Subsequently, the product of this process undergoes oxidative reactions resulting in the formation of advanced glycation end products (AGEs) (Fig 2-3) AGEs have been implicated in the aging process and agerelated diseases such as diabetes mellitus,1 3 chronic renal failure,4,5 and Alzheimer s disease 6 8 It is believed that with time, AGEs increase,9 accumulate on human collagen10 and elastin fibers,11 and contribute to aging of the skin As a result of glycation, collagen networks lose their ability to contract, and they become stiffer and resistant to remodeling Fibroblasts are key elements for collagen contracture, as they apply contracture force on the collagen lattice via their actin cytoskeleton12 Glycated collagen modifies the actin cytoskeleton of the fibroblasts thereby diminishing their collagen contraction capacity13 Fibroblasts also secrete collagenase (MMP-1), which is essential for collagen turnover Glycated collagen has been proven to decrease levels of collagenase I (MMP-1), leading to less tissue remodeling14 Studies have shown that UV exposure may also contribute to the production and function of AGEs N e -(carboxymethyl) lysine TABLE 2-1 Major Collagen Types Found in the Dermis COLLAGEN TYPE I III IV V VII XVII OTHER NAME Fetal collagen LOCATION Bone, tendon, skin Dermis, GI, vessels Basement membranes Dermis, diffusely distributed Anchoring brils Hemidesmosome FUNCTION Gives tensile strength Gives compliance Forms a lattice Unknown Stabilizes DEJ (CML) is one of the AGEs in which the amino side chain of lysine is reduced This product was shown to accumulate on elastin tissue of photoaged skin and proven to be higher in sun-exposed skin as compared to sun-protected skin11 In addition, it has been proposed that AGE-modified proteins act as endogenous photosensitizers in human skin via oxidative stress mechanisms induced by UVA light15.

The query shown in Listing 4-28 returns all employees with an uppercase A as the second character in their name. Listing 4-28. Using the LIKE Operator with the Percent and Underscore Characters SQL> select empno, init, ename 2 from employees 3 where ename like '_A%'; EMPNO -------7521 7654 SQL> Just like the BETWEEN and IN operators, the LIKE operator also features a built-in negation option; in other words, you can use WHERE . . . NOT LIKE . . . . The following queries show two special cases: one using LIKE without wildcards and one using the % character without the LIKE operator. SQL> select * from employees where ename like 'BLAKE' SQL> select * from employees where ename = 'BL%' Both queries will be executed by Oracle, without any complaints or error messages. However, in the first example, we could have used the equal sign (=) instead of the LIKE operator to get the same results. In the second example, the percent sign (%) has no special meaning, since it doesn t follow the LIKE operator, so it is very likely we would get back the no rows selected message. If you really want to search for actual percent sign or underscore characters with the LIKE operator, you need to suppress the special meaning of those characters. You can do this with the ESCAPE option of the LIKE operator, as demonstrated in Listing 4-29. INIT ----TF P ENAME -------WARD MARTIN

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create our workflow Follow these steps, again keeping in mind that which buttons you push to start and stop shooting the video depends on your particular camera: 1 Choose a subject to video: a pet, your spouse, a friend Make sure it s something that moves Plants probably won t cut it 2 Start your video recording at least a second before the action you want to capture begins This is called a lead-in When we get to editing footage in 2, you ll see why the lead-in is important For now it s more of a habit that you should try to adopt 3 Film your subject While filming, count out five seconds to yourself The maximum length of your video directly correlates to the amount of free memory you have on your phone 4 Just as it s a good idea to start with a lead-in, give at least one second of lead-out to your footage 5 Your phone should ask you whether you would like to save the video or discard it Save the footage We now have some real footage It may not be news-making, but that s not important here We need to do two things: first, check the video footage to make sure we captured what we thought we were recording, and second, save the footage either directly to the Web or to our editing tool

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